Publikacje

 

The Role of Telomerase in Breast Cancer’s Response to Therapy.
Judasz E., Lisiak N., Kopczyński P., Taube M., Rubiś B.

Int. J. Mol. Sci. 2022, 23, 12844. DOI: 10.3390/ijms232112844

No Association between ABCB1 G2677T/A or C3435T Polymorphisms and Survival of Breast Cancer Patients—A 10-Year Follow-Up Study in the Polish Population.
Totoń E., Jacczak B., Barczak W., Jagielski P., Gryczka R., Hołysz H., Grodecka-Gazdecka S., Rubiś B.

MDPI 2022,13, 729

Proapoptotic and proautophagic activity of 20-hydroxyecdysone in breast cancer cells in vitro.
Romaniuk-Drapała A., Lisiak N., Totoń E., Matysiak A., Nawrot J., Nowak G., Kaczmarek M., Rybczyńska M., Rubiś B.
Chem. Biol. Interact. 2021: Vol. 342:109479. DOI: 10.1016/j.cbi.2021.109479

Anti-SARS-CoV-2 strategies and the potential role of miRNA in the assessment of COVID-19 morbidity, recurrence, and therapy.
Narożna M., Rubiś B.
Int. J. Mol. Sci. 2021, 22, 8663. DOI: 10.3390/ijms22168663

Anti-leukemia activity of Au/CuO/ZnO nanoparticles synthesized used Verbena officinalis extract.
Dobrucka R., Romaniuk-Drapała A., Kaczmarek M.
J Inorg Organomet Polym 2021, 31, 191–202. DOI: 10.1007/s10904-020-01690-8

LEP (-2548G>A LEP) and LEPR (223Gln>Arg, 109Lys>Arg) polymorphisms as breast cancer risk factors in the Polish female population.
Hołysz H., Paszel-Jaworska A., Romaniuk-Drapała A., Grodecka-Gazdecka S., Rubiś B.
Mol. Biol. Rep. 2021: 1-8. DOI: 10.1007/s11033-021-06328-7

hTERT downregulation attenuates resistance to DOX, impairs FAK - mediated adhesion, and leads to autophagy induction in breast cancer cells.
Romaniuk-Drapała A., Totoń E., Konieczna N., Machnik M., Barczak W., Kowal D., Kopczyński P., Kaczmarek M., Rubiś B.
Cells 2021 : Vol. 10, nr 4: 867. DOI: 10.3390/cells10040867

Facile synthesis of Au/ZnO/Ag nanoparticles using Glechoma hederacea L. extract, and their activity against leukemia.
Dobrucka, R., Romaniuk-Drapała, A., Kaczmarek, M.
Biomed Microdevices 23, 14 (2021). DOI: 10.1007/s10544-021-00557-0

Addition of popular exogenous antioxidant agent, PBN, to culture media may be an important step to optimization of myogenic stem/progenitor cell preparation protocol.
Nowaczyk M., Malcher A., Zimna A., Łabędź, W., Kubaszewski Ł., Barczak W., Rubiś B., Rozwadowska N., Kurpisz M.
Antioxidants. 2021; 10(6):959. DOI: 10.3390/antiox10060959

Potential of naturally derived compounds in telomerase and telomere modulation in skin senescence and aging.
Jacczak, B., Rubiś B., Totoń E.
Int. J. Mol. Sci. 2021, 22, 6381. DOI: 10.3390/ijms22126381

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
Lisiak N.
Autophagy 2021 : Vol. 17 (1): 1-382, DOI: 10.1080/15548627.2020.1797280

Cytotoxic, analgesic and anti-inflammatory activity of colchicine and its C-10 sulfur containing derivatives.
Kurek, J., Myszkowski, K., Okulicz-Kozaryn, I., Kurant A., Kamińska E., Szulc M., Rubiś B., Kaczmarek M., Mikołajczak P., Murias M.
Sci Rep 2021, 11, 9034. DOI: 10.1038/s41598-021-88260-1

Zastosowanie leptyny rekombinowanej w leczeniu różnych typów lipodystrofii.

Hołysz H., Totoń E. Post. Hig. Med. Dośw. 2021, Vol. 75, 815-822. DOI: 10.2478/ahem-2021-0016

Contribution of Dopamine Transporter Gene Methylation Status to Cannabis Dependency.
Grzywacz A., Barczak W., Chmielowiec J., Chmielowiec K., Suchanecka A., Trybek G., Masiak J., Jagielski P., Grocholewicz K., Rubiś B.
Brain Sci. 2020 Jun 23;10(6):400. DOI: 10.3390/brainsci10060400.

Biologically synthesized of Au/Pt/ZnO nanoparticles using Arctium lappa extract and cytotoxic activity against leukemia.
Dobrucka, R., Romaniuk-Drapała, A., Kaczmarek, M.
Biomed Microdevices 22, 72 (2020). DOI: 10.1007/s10544-020-00526-z

Telomere length: how the length makes a difference.
Lulkiewicz M., Bajsert J., Kopczyński P., Barczak W., Rubiś B.
Mol. Biol. Rep. 2020 : Vol. 47, nr 9, s. 7181-7188. DOI: 10.1007/s11033-020-05551-y

Mucoadhesive chitosan delivery system with Chelidonii Herba lyophilized extract as a promising strategy for vaginitis treatment.
Paczkowska M., Chanaj-Kaczmarek J., Romaniuk-Drapała A., Rubiś B., Szymanowska D., Kobus-Cisowska J., Szymańska E., Winnicka K., Cielecka-Piontek J.
J. Clin. Med. 2020 : Vol. 9, nr 4, art. 1208:1-9. DOI: 10.3390/jcm9041208

Genetic Editing and Pharmacogenetics in Current and Future Therapy of Neurocognitive Disorders.
Prendecki M., Kowalska M., Toton E., Kozubski W.
Current Alzheimer Research 202017238-258. DOI: 10.2174/1567205017666200422152440

Effect of 3-o-acetylaleuritolic acid from in vitro-cultured Drosera spatulata on cancer cells survival and migration.

Totoń E., Kędziora I.,  Romaniuk-Drapała A., Konieczna N., Kaczmarek M., Lisiak N., Paszel-Jaworska A., Rybska A., Duszyńska W., Budzianowski J., Rybczyńska M., Rubiś B.

Pharm. Rep. 2020 January, pp 1-13. DOI: 10.1007/s43440-019-00008-x

Mammaglobin A as a diagnostic marker and therapeutic target in breast cancer.
Lisiak N., Sierszulska M., Bajsert J.
Post. Hig. Med. Dośw. 2020, 74: 566-571. DOI: 10.5604/01.3001.0014.5782

Evaluation of biological synthesized platinum nanoparticles using Ononidis radix extract on the cell lung carcinoma A549.
Dobrucka, R., Romaniuk-Drapała, A., Kaczmarek, M.
Biomed Microdevices 21, 75 (2019). DOI: 10.1007/s10544-019-0424-7

Telomerase Inhibitor TMPyP4 Alters Adhesion and Migration of Breast-CancerCells MCF7 and MDA-MB-231.
Konieczna N., Romaniuk-Drapała A., Lisiak N., Totoń E., Paszel-Jaworska A., Kaczmarek M., Rubiś B.
Int J Mol Sci. 2019 May 30; 20(11). pii: E2670. DOI: 10.3390/ijms20112670.

Vitamin C increases DNA breaks and suppresses DNA damage-independent activation of ATM by bleomycin.
Rubis B., Luczak M.W., Krawic C., Zhitkovich A.
Free Radic Biol Med. 2019 May 20;136:12-21. DOI: 10.1016/j.freeradbiomed.2019.03.026. Epub 2019 Mar 26.

Vitamin C as a Modulator of the Response to Cancer Therapy.
Blaszczak W., Barczak W., Masternak J., Kopczyński P., Zhitkovich A., Rubiś B.
Molecules. 2019 Jan 28;24(3). pii: E453. DOI: 10.3390/molecules24030453.

The non-canonical functions of telomerase: to turn off or not to turn off.

Romaniuk A., Paszel-Jaworska A., Totoń E., Lisiak N., Hołysz H., Królak A., Grodecka-Gazdecka S., Rubiś B.

Mol Biol Rep. 2019 Feb;46(1):1401-1411. DOI: 10.1007/s11033-018-4496-x.

Binding Study of the Fluorescent Carbazole Derivative with Human Telomeric G-Quadruplexes.
Głuszyńska A., Juskowiak B., Rubiś B.
Molecules. 2018 Nov 30;23(12). pii: E3154. DOI: 10.3390/molecules23123154.

Pleural Macrophages can Promote or Inhibit Apoptosis of Malignant Cells via Humoral Mediators Depending on Intracellular Signaling Pathways.

Kaczmarek M., Rubis B., Frydrychowicz M., Nowicka A., Brajer-Luftmann B., Kozlowska M., Lagiedo M., Batura-Gabryel H., Sikora J.

Cancer Invest. 2018;36(5):264-278. DOI: 10.1080/07357907.2018.1477158. Epub 2018 Jul 23.

hTERT promoter methylation status in peripheral blood leukocytes as a molecular marker of head and neck cancer progression.
Sobecka A., Blaszczak W., Barczak W., Golusinski P., Rubis B., Masternak M.M., Suchorska W.M., Golusinski W.
J Appl Genet. 2018 Aug 7. DOI: 10.1007/s13353-018-0458-1

Serum from patients with chronic obstructive pulmonary disease induces senescence-related phenotype in bronchial epithelial cells.
Kuźnar-Kamińska B., Mikuła-Pietrasik J., Witucka A., Romaniuk A., Konieczna N., Rubiś B., Książek K., Tykarski A., Batura-Gabryel H.
Sci Rep. 2018 Aug 28;8(1):12940. DOI: 10.1038/s41598-018-31037

Pleural Macrophages can Promote or Inhibit Apoptosis of Malignant Cells via Humoral Mediators Depending on Intracellular Signaling Pathways.
Kaczmarek M., Rubis B., Frydrychowicz M., Nowicka A., Brajer-Luftmann B., Kozlowska M., Lagiedo M., Batura-Gabryel H., Sikora J.
Cancer Invest. 2018; 36(5): 264-278. DOI: 10.1080/07357907.2018.1477158

hTERT gene knockdown enhances response to radio- and chemotherapy in head and neck cancer cell lines through a DNA damage pathway modification.
Barczak W., Sobecka A., Golusinski P., Masternak M.M., Rubiś B., Suchorska W.M., Golusinski W.
Sci Rep. 2018 Apr 13;8(1):5949. DOI: 10.1038/s41598-018-24503-y.

Autophagy as a Potential Therapeutic Target in Breast Cancer Treatment.
Lisiak N., Toton E., Rybczynska M.
Curr Cancer Drug Targets. 2017 Nov 14. DOI: 10.2174/1568009617666171114143330

Impact of PKCε downregulation on autophagy in glioblastoma cells.
Totoń E., Romaniuk A., Konieczna N., Hofmann J., Barciszewski J., Rybczyńska M.
BMC Cancer 2018: Vol. 18; 185: 1-17. DOI: 10.1186/s12885-018-4095-1

Telomerase and drug resistance in cancer.
Lipińska N., Romaniuk A., Paszel-Jaworska A., Toton E., Kopczynski P., Rubis B.
Cell Mol Life Sci. 2017: Vol. 74: 4121-4132. DOI: 10.1007/s00018-017-2573-2

hTERT C250T promoter mutation and telomere length as a molecular markers of cancer progression in patients with head and neck cancer.
Barczak W., Suchorska W., Sobecka A., Bednarowicz K., Machczyński P., Golusiński P., Rubiś B., Masternak M.M., Golusiński W.
Mol. Med. Rep. 2017: Vol. 16, nr 1, s. 441-446. DOI: 10.3892/mmr.2017.6590

Nanoscale size effect in in situ titanium based composites with cell viability and cytocompatibility studies.
Miklaszewski A., Jurczyk M.U., Kaczmarek M., Paszel-Jaworska A., Romaniuk A., Lipińska N., Żurawski J., Urbaniak P., Jurczyk M.
Mater. Sci. Eng. C Mater. Biol. Appl. 2017: Vol. 73, s. 525-536. DOI: 10.1016/j.msec.2016.12.100

Semisynthetic oleanane triterpenoids inhibit migration and invasion of human breast cancer cells through downregulated expression of the ITGB1/PTK2/PXN pathway.
Lisiak N., Paszel-Jaworska A., Totoń E., Rubiś B., Pakuła M., Bednarczyk-Cwynar B., Zaprutko L., Rybczyńska M.
Chem. Biol. Interact. 2017: Vol. 268, s. 136-147. DOI: 10.1016/j.cbi.2017.03.008

Strain-dependent mutational effects for Pepino mosaic virus in a natural host.
Minicka J., Elena S.F., Borodynko-Filas N., Rubiś B., Hasiów-Jaroszewska B.
BMC Evol. Biol. 2017: Vol. 17, nr 1, art. 67, s. 1-11. DOI: 10.1186/s12862-017-0920-4 

Effect of growth differentiation factor-9 C447T and G546A polymorphisms on the outcomes of in vitro fertilization.
Serdyńska-Szuster M., Jędrzejczak P., Ożegowska K.E., Hołysz H., Pawelczyk L., Jagodziński P.P.
Mol. Med. Rep. 2016: Vol. 13, nr 5, s. 4437-4442. DOI: 10.3892/mmr.2016.5060

Formaldehyde is a potent proteotoxic stressor causing rapid heat shock transcription factor 1 activation and Lys48-linked polyubiquitination of proteins.
Ortega-Atienza S., Rubiś B., McCarthy C., Zhitkovich A.
Am. J. Pathol. 2016: Vol. 186, nr 11, s. 2857-2868. DOI: 10.1016/j.ajpath.2016.06.022

In vitro biocompatibility of anodized titanium with deposited silver nanodendrites.
Kaczmarek M., Jurczyk K., Koper J.K., Paszel-Jaworska A., Romaniuk A., Lipińska N., Żurawski J., Urbaniak P., Jakubowicz J., Jurczyk M.U.
J. Mater. Sci. 2016: Vol. 51, nr 11, s. 5259-5270. DOI: 10.1007/s10853-016-9829-3

In vitro biocompatibility of titanium after plasma surface alloying with boron
Kaczmarek M., Jurczyk M.U., Miklaszewski A., Paszel-Jaworska A., Romaniuk A., Lipińska N., Żurawski J., Urbaniak P., Jurczyk K.
Mater. Sci. Eng. C Mater. Biol. Appl. 2016: Vol. 69, s. 1240-1247. DOI: 10.1016/j.msec.2016.08.006

Increased proapoptotic activity of electron beam irradiated doxorubicin and epirubicin in multidrug-resistant human leukemic cells.
Paszel-Jaworska A., Totoń, Dettlaff K., Kaczmarek A., Bednarski W., Oszczapowicz I., Jelińska A., Rybczyńska M.
Chem. Biol. Interact. 2016: Vol. 258, s. 69-78. DOI: 10.1016/j.cbi.2016.08.011

Novel promising estrogenic receptor modulators: cytotoxic and estrogenic activity of benzanilides and dithiobenzanilides.
Kucińska M., Giron M.D., Piotrowska H., Lisiak N., Granig W.H., Lopez-Jaramillo F.J., Salto R., Murias M., Erker T.
PLoS ONE 2016: Vol. 11, nr 1, e0145615, s. 1-16. DOI: 10.1371/journal.pone.0145615

Selective anticancer activity of the novel thiobenzanilide 63T against human lung adenocarcinoma cells.
Kucińska M., Piotrowska-Kempisty H., Lisiak N., Kaczmarek M., Dams-Kozłowska H., Granig W.H., Höferl M., Jäger W., Zehl M., Murias M., Erker T.
Toxicol. In Vitro 2016: Vol. 37, s. 148-161. DOI: 10.1016/j.tiv.2016.09.017

Telomere length assessment in leukocytes presents potential diagnostic value in patients with breast cancer.
Barczak W., Rozwadowska N., Romaniuk A., Lipińska N., Lisiak N., Grodecka-Gazdecka S., Książek K., Rubiś B.
Oncol. Lett. 2016: Vol. 11, nr 3, s. 2305-2309. DOI: 10.3892/ol.2016.4188

The synthetic oleanane triterpenoid HIMOXOL induces autophagy in breast cancer cells via ERK1/2 MAPK pathway and Beclin-1 up-regulation.
Lisiak N., Totoń E., Rubiś B., Majer B., Rybczyńska M.
Anticancer Agents Med. Chem. 2016: Vol. 16, nr 8, s. 1066-1076. DOI: 10.2174/1871520616666160223114104

Zapotin (5,6,2',6'-tetramethoxyflavone) modulates the crosstalk between autophagy and apoptosis pathways in cancer cells with overexpressed constitutively active PKC.
Totoń E., Romaniuk A., Budzianowski J., Hofmann J., Rybczyńska M.
Nutr. Cancer 2016: Vol. 68, nr 2, s. 290-304. DOI: 10.1080/01635581.2016.1134595

DAT1 methylation changes in alcohol-dependent individuals vs. controls.
Jasiewicz A., Rubiś B., Samochowiec J., Małecka I., Suchanecka A., Jabłoński M., Grzywacz A.
J. Psychiatr. Res. 2015: Vol. 64, s. 130-133. DOI: 10.1016/j.jpsychires.2015.03.007

Impact of common ABCB1 polymorphism on pharmacokinetics and pharmacodynamics of clopidogrel and its metabolites.
Karaźniewicz-Łada M., Danielak D., Rubiś B., Burchardt P., Komosa A., Lesiak M., Główka F.
J. Clin. Pharm. Ther. 2015: Vol. 40, nr 2, s. 226-231. DOI: 10.1111/jcpt.12236

Proapoptotic activity and ABCC1-related multidrug resistance reduction ability of semisynthetic oleanolic acid derivatives DIOXOL and HIMOXOL in human acute promyelocytic leukemia cells.
Paszel-Jaworska A., Rubiś B., Bednarczyk-Cwynar B., Zaprutko L., Rybczyńska M.
Chem. Biol. Interact. 2015: Vol. 242, s. 1-12. DOI: 10.1016/j.cbi.2015.07.011.

Telomere shortening in Down syndrome patients - when does it start?
Gruszeczka A., Kopczyński P., Cudziło D., Lipińska N., Romaniuk A., Barczak W., Rozwadowska N., Totoń E., Rubiś B.
DNA Cell Biol. 2015: Vol. 34, nr 6, s. 412-417. DOI: 10.1089/dna.2014.2746

Universal real-time PCR-based assay for lentiviral titration.
Barczak W., Suchorska W., Rubiś B., Kulcenty K.
Mol. Biotechnol. 2015: Vol. 57, nr 2, s. 195-200. DOI: 10.1007/s12033-014-9815-4

Autofagia, nowe perspektywy w terapii przeciwnowotworowej.
Lisiak N., Totoń E., Rybczyńska M.
Post. Hig. Med. Dośw. 2014: T. 68, s. 925-935.

Beclin-1 and its role as a target for anticancer therapy.
Totoń E., Lisiak N., Sawicka P., Rybczyńska M.
J. Physiol. Pharmacol. 2014: Vol. 65, nr 4, s. 459-467.

In vitro biocompatibility of Ti-45S5 bioglass nanocomposites and their scaffolds.
Kaczmarek M., Jurczyk M.U.,  Rubiś B., Banaszak A., Kolecka A., Paszel A., Jurczyk K., Murias M., Sikora J., Jurczyk M.
J. Biomed. Mater. Res. A 2014: Vol. 102A, nr 5, s. 1316-1324. DOI: 10.1002/jbm.a.34808

Methyl 3-hydroxyimino-11-oxoolean-12-en-28-oate (MIXOMOL), a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MDA-MB-231 breast cancer cells.
Lisiak N., Paszel-Jaworska A., Bednarczyk-Cwynar B., Zaprutko L., Kaczmarek M., Rybczyńska M.
Chem. Biol. Interact. 2014: Vol. 208, s. 47-57. DOI: 10.1016/j.cbi.2013.11.009

Molecular mechanisms of biological activity of oleanolic acid - a source of inspiration for a new drugs design.
Paszel-Jaworska A., Romaniuk A., Rybczyńska M.
Mini Rev. Org. Chem. 2014: Vol. 11, nr 3, s. 330-342. DOI:10.2174/1570193X1103140915111839

Telomerase modulation in therapeutic approach.
Romaniuk A., Kopczyński P., Książek K., Rubiś B.
Curr. Pharm. Des. 2014: Vol. 20, nr 41, s. 6438-6451. DOI: 10.2174/1381612820666140630092721

The influence of genetic polymorphism of Cyp2c19 isoenzyme on the pharmacokinetics of clopidogrel and its metabolites in patients with cardiovascular diseases.
Karaźniewicz-Łada M., Danielak D., Rubiś B., Burchardt P., Oszkinis G., Główka F.
J. Clin. Pharmacol. 2014: Vol. 54, nr 8, s. 874-880. DOI: 10.1002/jcph.323